GH RESPONSE TO GRF IN HYPOTHYROID CHILDREN
نویسندگان
چکیده
منابع مشابه
GH deficiency status combined with GH receptor polymorphism affects response to GH in children
Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatmen...
متن کاملComparison between the growth response to growth hormone (GH) therapy in children with partial GH insensitivity or mild GH deficiency.
OBJECTIVES GH therapy is still controversial, except in severe GH deficiency (SGHD). The objective of this study was to compare the response to growth hormone (GH) therapy in children with partial GH insensitivity (PGHIS) and mild GH deficiency (MGHD) with those with SGHD. SUBJECTS AND METHODS Fifteen PGHIS, 11 MGHD, and 19 SGHD subjects, followed up for more than one year in the Brazilian pu...
متن کاملEffects of TRH and GRF administration on GH, TSH, T4 and T3 secretion in the lamb.
The effects of various amounts of thyrotropin-releasing hormone (TRH) injected subcutaneously or intravenously (alone or in combination with growth hormone-releasing factor: GRF 1-44) on growth hormone (GH), thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3) were studied in the plasma of 2-week, 2-month and 3-month old lambs. After subcutaneous TRH administration, incre...
متن کاملGrowth hormone (GH) provocation tests and the response to GH treatment in GH deficiency.
OBJECTIVE To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD). SUBJECTS A total of 337 prepubertal GHD patients aged <10 years from the UK Pharmacia KIGS database (GH response to provocation test <20 mU/l). OUTCOME MEASURE Annual change in height standard deviation score (SDS) (revi...
متن کاملPlasma GH response to hpGRF-44 in normal children of short stature and patients with GH deficiency.
Synthetic human pancreatic GRF (hpGRF-44) was administered as an iv bolus to 139 normal children of short stature and 63 patients with GH deficiency. After a dose of 1 and 2 micrograms hpGRF-44/kg BW, mean plasma GH levels peaked at 15 and 30 min, respectively, with corresponding values of 32.2 +/- 3.6 and 31.8 +/- 2.4 (+/- SE) ng/ml in normal but short children. There were no differences accor...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1988
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198801000-00122